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Machine Learning

A collection of articles and resources on clinical applications of machine learning.

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RESEARCH

Original Investigation

Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain

John D. Piette, MSc, PhD, Sean Newman, MS et al.

Original Investigation

External Validation of a Widely Implemented Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, MD, Erkin Otles, MEng et al.

Research Letter

Global Media Coverage of the Benefits and Harms of Early Detection Tests

Mary O’Keeffe, PhD, Alexandra Barratt, MD et al.

Original Investigation

Concordance Between Blood Pressure in SPRINT and in Routine Clinical Practice

Paul E. Drawz, MD, MHS, MS, Anil Agarwal, MD et al.

Original Investigation

Detection of Pathogenic Variants With Germline Genetic Testing in Patients With Prostate Cancer and Melanoma

Saud H. AlDubayan, MD, Jake R. Conway, BSc et al.

Research Letter

Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms

Amit Kaushal, MD, PhD, Russ Altman, MD, PhD et al.

Preliminary Communication

Effect of a Machine Learning–Derived Early Warning System vs Standard Care on Hypotension During Noncardiac Surgery

Marije Wijnberge, MD, Bart F. Geerts, MD, PhD, MSc, MBA et al.

Research Letter

Automatically Charting Symptoms From Patient-Physician Conversations Using Machine Learning

Alvin Rajkomar, MD, Anjuli Kannan, AB et al.

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches

Thomas H. McCoy Jr, MD, Roy H. Perlis, MD, MSc

Original Investigation

Machine Learning Screen for Diabetic Retinopathy and Other Eye Diseases

Daniel Shu Wei Ting, MD, PhD, Carol Yim-Lui Cheung, PhD et al.

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REVIEW

Users' Guides to the Medical Literature

How to Read Articles That Use Machine Learning

Yun Liu, PhD, Po-Hsuan Cameron Chen, PhD et al.

JAMA Guide to Statistics and Methods

On Deep Learning for Medical Image Analysis

Lawrence Carin, PhD, Michael J. Pencina, PhD

OPINION

Viewpoint

Decoding Artificial Intelligence to Achieve Diagnostic Excellence

Jonathan H. Chen, MD, PhD, Gurpreet Dhaliwal, MD et al.

Viewpoint

Rethinking Algorithm Performance Metrics for Artificial Intelligence in Diagnostic Medicine

Matthew A. Reyna, PhD, MS, Elaine O. Nsoesie, PhD et al.

Viewpoint

Preparing Clinicians for a Clinical World Influenced by Artificial Intelligence

Cornelius A. James, MD, Robert M. Wachter, MD et al.

Viewpoint

Proactive vs Reactive Machine Learning in Health Care

Yuan Luo, PhD, Richard G. Wunderink, MD et al.

Viewpoint

Preventing Digital Overdiagnosis

Daniel Capurro, MD, PhD, Simon Coghlan, PhD et al.

Viewpoint

Next-Generation Artificial Intelligence for Diagnosis

Julia Adler-Milstein, PhD, Jonathan H. Chen, MD, PhD et al.

Viewpoint

Modernizing Public Health Data Systems

Kushal T. Kadakia, MSc, Michael D. Howell, MD, MPH et al.

Editorial

Importance of External Validation in Sepsis

Anand R. Habib, MD, MPhil, Anthony L. Lin, MD et al.

Viewpoint

Leveraging the Medicare Program for a COVID-19 Vaccination Campaign

Nicole Lurie, MD, MSPH, Bettina Experton, MD, MPH

Invited Commentary

A Tale of 2 Blood Pressures

John A. Dodson, MD, MPH, Daichi Shimbo, MD

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SPECIALTY MACHINE LEARNING
Cardiology
Machine Learning and Social Determinants of Health JAMA Cardiology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Challenges During Implementation of Clinical Decision Support Systems JAMA Network Open |
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
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SPECIALTY MACHINE LEARNING
Dermatology
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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SPECIALTY MACHINE LEARNING
Cardiology
Dermatology
Machine Learning and Social Determinants of Health JAMA Cardiology |
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
Challenges During Implementation of Clinical Decision Support Systems JAMA Network Open |
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
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Neurology
Choosing the Best Antiseizure Medication JAMA Neurology |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
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Oncology
Variation in and Factors Associated With US County-Level Cancer Mortality, 2008-2019 JAMA Network Open |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
Maximizing Cancer Data—The Future of Cancer Is Now JAMA Oncology |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
Barriers to Electronic Patient-Reported Outcome Measurement Among LEP Patients with Cancer JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Generative Adversarial Networks for Oncological Applications JAMA Oncology |
Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer JAMA Network Open |
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Neurology
Oncology
Variation in and Factors Associated With US County-Level Cancer Mortality, 2008-2019 JAMA Network Open |
Choosing the Best Antiseizure Medication JAMA Neurology |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
Maximizing Cancer Data—The Future of Cancer Is Now JAMA Oncology |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Barriers to Electronic Patient-Reported Outcome Measurement Among LEP Patients with Cancer JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Generative Adversarial Networks for Oncological Applications JAMA Oncology |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer JAMA Network Open |
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Ophthalmology
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
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Otolaryngology
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Ophthalmology
Otolaryngology
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Pediatrics
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
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Psychiatry
Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain JAMA Internal Medicine |
Machine Learning Analysis of Handgun Transactions to Predict Firearm Suicide Risk JAMA Network Open |
Predicting Firearm Suicide JAMA Network Open |
Analysis of Access to Prescription Data Management Programs Data for Research JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Comparison of Methods to Reduce Bias From Clinical Prediction Models of Postpartum Depression JAMA Network Open |
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Pediatrics
Psychiatry
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain JAMA Internal Medicine |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Predicting Firearm Suicide JAMA Network Open |
Analysis of Access to Prescription Data Management Programs Data for Research JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Comparison of Methods to Reduce Bias From Clinical Prediction Models of Postpartum Depression JAMA Network Open |
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Surgery
Evaluation of a Model for Laparoscopic Colorectal Surgical Instrument Recognition JAMA Network Open |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Distinct Subtypes of Black Kidney Transplant Recipients JAMA Surgery |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
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Radiology
Association of AI-Aided Chest Radiograph Interpretation With Reader Performance and Efficiency JAMA Network Open |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Analysis of Radiology Report Recommendations and Rate of Recommended Action Performance JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Artificial Intelligence in Medical Imaging JAMA Health Forum |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
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Surgery
Radiology
Evaluation of a Model for Laparoscopic Colorectal Surgical Instrument Recognition JAMA Network Open |
Association of AI-Aided Chest Radiograph Interpretation With Reader Performance and Efficiency JAMA Network Open |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Distinct Subtypes of Black Kidney Transplant Recipients JAMA Surgery |
Analysis of Radiology Report Recommendations and Rate of Recommended Action Performance JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Artificial Intelligence in Medical Imaging JAMA Health Forum |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
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In-Person vs Video Training and Full vs Limited Function in Inpatient Portal Use

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Crowdsourcing to Develop Machine Learning Models to Quantify Joint Damage in RA

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Development and Validation of Machine Models to Classify Substances Involved in Overdose

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Invited Commentary

Quality Dashboard for Individuals With Complex Care Needs

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Consensus Statement

Quality Measures for Patients at Risk of Adverse Outcomes in the VHA

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Original Investigation

Utilization of Electronic Consultations Among US Academic Medical Centers During the COVID-19 Pandemic

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Estimating Opioid Overdose Deaths in Near Real Time Using Proxy Data Sources

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