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Machine Learning

A collection of articles and resources on clinical applications of machine learning.

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RESEARCH

Original Investigation

Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age

Chuan Hong, PhD, Michael J. Pencina, PhD et al.

Original Investigation

Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain

John D. Piette, MSc, PhD, Sean Newman, MS et al.

Original Investigation

External Validation of a Widely Implemented Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, MD, Erkin Otles, MEng et al.

Research Letter

Global Media Coverage of the Benefits and Harms of Early Detection Tests

Mary O’Keeffe, PhD, Alexandra Barratt, MD et al.

Original Investigation

Concordance Between Blood Pressure in SPRINT and in Routine Clinical Practice

Paul E. Drawz, MD, MHS, MS, Anil Agarwal, MD et al.

Original Investigation

Detection of Pathogenic Variants With Germline Genetic Testing in Patients With Prostate Cancer and Melanoma

Saud H. AlDubayan, MD, Jake R. Conway, BSc et al.

Research Letter

Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms

Amit Kaushal, MD, PhD, Russ Altman, MD, PhD et al.

Preliminary Communication

Effect of a Machine Learning–Derived Early Warning System vs Standard Care on Hypotension During Noncardiac Surgery

Marije Wijnberge, MD, Bart F. Geerts, MD, PhD, MSc, MBA et al.

Research Letter

Automatically Charting Symptoms From Patient-Physician Conversations Using Machine Learning

Alvin Rajkomar, MD, Anjuli Kannan, AB et al.

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches

Thomas H. McCoy Jr, MD, Roy H. Perlis, MD, MSc

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REVIEW

Special Communication

Artificial Intelligence in Breast Cancer Screening

Kunal C. Potnis, BS, Joseph S. Ross, MD, MHS et al.

Users' Guides to the Medical Literature

How to Read Articles That Use Machine Learning

Yun Liu, PhD, Po-Hsuan Cameron Chen, PhD et al.

JAMA Guide to Statistics and Methods

On Deep Learning for Medical Image Analysis

Lawrence Carin, PhD, Michael J. Pencina, PhD

OPINION

Viewpoint

Clinical Algorithms, Antidiscrimination Laws, and Medical Device Regulation

Katherine E. Goodman, PhD, JD, Daniel J. Morgan, MD, MS et al.

Viewpoint

Prevention of Bias and Discrimination in Clinical Practice Algorithms

Carmel Shachar, JD, MPH, Sara Gerke, Dipl-Jur Univ, MA

Viewpoint

Decoding Artificial Intelligence to Achieve Diagnostic Excellence

Jonathan H. Chen, MD, PhD, Gurpreet Dhaliwal, MD et al.

Viewpoint

Rethinking Algorithm Performance Metrics for Artificial Intelligence in Diagnostic Medicine

Matthew A. Reyna, PhD, MS, Elaine O. Nsoesie, PhD et al.

Viewpoint

Preparing Clinicians for a Clinical World Influenced by Artificial Intelligence

Cornelius A. James, MD, Robert M. Wachter, MD et al.

Viewpoint

Proactive vs Reactive Machine Learning in Health Care

Yuan Luo, PhD, Richard G. Wunderink, MD et al.

Viewpoint

Preventing Digital Overdiagnosis

Daniel Capurro, MD, PhD, Simon Coghlan, PhD et al.

Viewpoint

Next-Generation Artificial Intelligence for Diagnosis

Julia Adler-Milstein, PhD, Jonathan H. Chen, MD, PhD et al.

Viewpoint

Modernizing Public Health Data Systems

Kushal T. Kadakia, MSc, Michael D. Howell, MD, MPH et al.

Editorial

Importance of External Validation in Sepsis

Anand R. Habib, MD, MPhil, Anthony L. Lin, MD et al.

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SPECIALTY MACHINE LEARNING
Cardiology
Physiologic Monitoring Strategies in the Emergency Department JAMA Network Open |
Machine Learning and Social Determinants of Health JAMA Cardiology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Challenges During Implementation of Clinical Decision Support Systems JAMA Network Open |
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SPECIALTY MACHINE LEARNING
Dermatology
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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SPECIALTY MACHINE LEARNING
Cardiology
Dermatology
Physiologic Monitoring Strategies in the Emergency Department JAMA Network Open |
Machine Learning and Social Determinants of Health JAMA Cardiology |
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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Neurology
Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age JAMA |
Choosing the Best Antiseizure Medication JAMA Neurology |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
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Oncology
Algorithm to Differentiate Colon Carcinoma From Diverticulitis in Computed Tomography Images JAMA Network Open |
Machine Learning Model for Detection and Classification of Tertiary Lymphoid Structures JAMA Network Open |
An Algorithm as a Biomarker for Response to Immune Checkpoint Inhibitor Therapy JAMA Oncology |
Can The Matrix Help Treat Recurrent Hepatocellular Carcinoma? JAMA Surgery |
Artificial Intelligence in Breast Cancer Screening JAMA Internal Medicine |
Validation of a Model for Automated Mammography Interpretation by Artificial Intelligence JAMA Network Open |
The Need for Targeted Labeling of Machine Learning–Based Software as a Medical Device JAMA Network Open |
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Neurology
Oncology
Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age JAMA |
Algorithm to Differentiate Colon Carcinoma From Diverticulitis in Computed Tomography Images JAMA Network Open |
Machine Learning Model for Detection and Classification of Tertiary Lymphoid Structures JAMA Network Open |
Choosing the Best Antiseizure Medication JAMA Neurology |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
An Algorithm as a Biomarker for Response to Immune Checkpoint Inhibitor Therapy JAMA Oncology |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Can The Matrix Help Treat Recurrent Hepatocellular Carcinoma? JAMA Surgery |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Artificial Intelligence in Breast Cancer Screening JAMA Internal Medicine |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Validation of a Model for Automated Mammography Interpretation by Artificial Intelligence JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
The Need for Targeted Labeling of Machine Learning–Based Software as a Medical Device JAMA Network Open |
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Ophthalmology
Identifying Retinopathy of Prematurity Regression and Reactivation Using Vascular Severity Score JAMA Network Open |
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
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Otolaryngology
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Ophthalmology
Otolaryngology
Identifying Retinopathy of Prematurity Regression and Reactivation Using Vascular Severity Score JAMA Network Open |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Pediatrics
Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease JAMA Network Open |
Racial and Ethnic Disparities in Geographic Access to Autism Resources Across the US JAMA Network Open |
Identifying Retinopathy of Prematurity Regression and Reactivation Using Vascular Severity Score JAMA Network Open |
Newborn Cry Acoustics in the Assessment of Neonatal Opioid Withdrawal Syndrome JAMA Network Open |
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
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Psychiatry
Racial and Ethnic Disparities in Geographic Access to Autism Resources Across the US JAMA Network Open |
Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain JAMA Internal Medicine |
Machine Learning Analysis of Handgun Transactions to Predict Firearm Suicide Risk JAMA Network Open |
Predicting Firearm Suicide JAMA Network Open |
Analysis of Access to Prescription Data Management Programs Data for Research JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
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Pediatrics
Psychiatry
Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease JAMA Network Open |
Racial and Ethnic Disparities in Geographic Access to Autism Resources Across the US JAMA Network Open |
Identifying Retinopathy of Prematurity Regression and Reactivation Using Vascular Severity Score JAMA Network Open |
Artificial Intelligence and Cognitive Behavioral Therapy for Chronic Back Pain JAMA Internal Medicine |
Newborn Cry Acoustics in the Assessment of Neonatal Opioid Withdrawal Syndrome JAMA Network Open |
Machine Learning Analysis of Handgun Transactions to Predict Firearm Suicide Risk JAMA Network Open |
Predicting Firearm Suicide JAMA Network Open |
External Validation of an ROP Screening Model in Low- and Middle-Income Populations JAMA Ophthalmology |
Analysis of Access to Prescription Data Management Programs Data for Research JAMA Network Open |
A Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
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Surgery
Can The Matrix Help Treat Recurrent Hepatocellular Carcinoma? JAMA Surgery |
Association Between the Patient-Physician Relationship and Completion of Bariatric Surgery JAMA Network Open |
Validation of a Prediction Model for Need for Massive Transfusion JAMA Network Open |
Use of a Prediction Model to Enhance Early Detection of Need for Massive Transfusion JAMA Network Open |
FDA Approves Artificial Intelligence Device for Guiding Regional Anesthesia JAMA |
Machine Learning Models Using Perioperative Data for Mortality After Cardiac Surgery JAMA Network Open |
Prediction of Epstein-Barr Virus Status in Gastric Cancer Biopsy Specimens JAMA Network Open |
Evaluation of a Model for Laparoscopic Colorectal Surgical Instrument Recognition JAMA Network Open |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
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Radiology
Algorithm to Differentiate Colon Carcinoma From Diverticulitis in Computed Tomography Images JAMA Network Open |
Development of a Machine Learning Model for Sonographic Assessment of Gestational Age JAMA Network Open |
Artificial Intelligence Model for Detection of Pneumothorax in Chest Radiographs JAMA Network Open |
FDA Approves Artificial Intelligence Device for Guiding Regional Anesthesia JAMA |
Validation of a Model for Automated Mammography Interpretation by Artificial Intelligence JAMA Network Open |
The Need for Targeted Labeling of Machine Learning–Based Software as a Medical Device JAMA Network Open |
Association of AI-Aided Chest Radiograph Interpretation With Reader Performance and Efficiency JAMA Network Open |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Analysis of Radiology Report Recommendations and Rate of Recommended Action Performance JAMA Network Open |
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Surgery
Radiology
Can The Matrix Help Treat Recurrent Hepatocellular Carcinoma? JAMA Surgery |
Development of a Machine Learning Model for Sonographic Assessment of Gestational Age JAMA Network Open |
Association Between the Patient-Physician Relationship and Completion of Bariatric Surgery JAMA Network Open |
Artificial Intelligence Model for Detection of Pneumothorax in Chest Radiographs JAMA Network Open |
Validation of a Prediction Model for Need for Massive Transfusion JAMA Network Open |
FDA Approves Artificial Intelligence Device for Guiding Regional Anesthesia JAMA |
Use of a Prediction Model to Enhance Early Detection of Need for Massive Transfusion JAMA Network Open |
Validation of a Model for Automated Mammography Interpretation by Artificial Intelligence JAMA Network Open |
FDA Approves Artificial Intelligence Device for Guiding Regional Anesthesia JAMA |
The Need for Targeted Labeling of Machine Learning–Based Software as a Medical Device JAMA Network Open |
Machine Learning Models Using Perioperative Data for Mortality After Cardiac Surgery JAMA Network Open |
Association of AI-Aided Chest Radiograph Interpretation With Reader Performance and Efficiency JAMA Network Open |
Prediction of Epstein-Barr Virus Status in Gastric Cancer Biopsy Specimens JAMA Network Open |
Model to Identify Critical Brain Injuries Using Natural Language Processing JAMA Network Open |
Evaluation of a Model for Laparoscopic Colorectal Surgical Instrument Recognition JAMA Network Open |
A Deep Learning Model for Brain Tumor Diagnosis and Classification Using MRI JAMA Network Open |
Artificial Intelligence and Optimal Margin Width for Colorectal Cancer Liver Metastases JAMA Surgery |
Analysis of Radiology Report Recommendations and Rate of Recommended Action Performance JAMA Network Open |
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Original Investigation

Association of Neighborhood Racial and Ethnic Composition With Built Environment Indicators

Yukun Yang, MS, Ahyoung Cho, MPP et al.

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Original Investigation

Effect of Machine Learning Recommender and Viral Peer Marketing on Smoking Cessation

Jamie M. Faro, PhD, Jinying Chen, PhD et al.

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Machine Learning to Estimate Adverse Outcome Risk With Opioid Dispensation

Vishal Sharma, MSc, Vinaykumar Kulkarni, MSc et al.

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Research Letter

Patient Use of Physicians’ First (Given) Name in Direct Patient Electronic Messaging

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Original Investigation

Randomized Clinical Trials of Machine Learning Interventions in Health Care

Deborah Plana, BS, Dennis L. Shung, MD, PhD et al.

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Original Investigation

In-Person vs Video Training and Full vs Limited Function in Inpatient Portal Use

Ann Scheck McAlearney, ScD, MS, Daniel M. Walker, PhD, MPH et al.

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Original Investigation

Clinician Diagnostic Concordance With Video Telemedicine at Mayo Clinic From March to June 2020

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Original Investigation

Crowdsourcing to Develop Machine Learning Models to Quantify Joint Damage in RA

Dongmei Sun, PhD, MSPH, Thanh M. Nguyen, PhD et al.

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Original Investigation

Assessment of Adherence to Reporting Guidelines by Commonly Used Prediction Models

Jonathan H. Lu, MS, Alison Callahan, PhD et al.

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Development and Validation of Machine Models to Classify Substances Involved in Overdose

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